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Publications

5. Reconstruction of craniofacial defects with bone-marrow-coated Polycaprolactone scaffolds, Craniofacial Surgery, 2001, 9:109-111.

6. Fused deposition modeling of novel scaffold architectures for tissue engineering applications, Biomaterials, 23 (2002): 1169-1185.

7. Induction of ectopic bone formation by using human periosteal cells in combination with a novel scaffold technology, Cell Transplantation, 11 (2002): 125-138.

8. Application of a X-ray microscopy technique to evaluate tissue engineered bone-scaffold constructs, Mat Sci and Eng: C (Special Issue on Biomaterials and Tissue Engineering): 20 (2002): 9-17.

9. Tissue engineering challenges and issues – the Asian perspective, Tissue Engineering, 9 (Sup 1) (2003): S1-S3.

10. Scaffold design and in vitro study of osteochondral co-culture in a 3D porous polycaprolactone scaffold fabricated by fused fused deposition modelling, Tissue Engineering, 9 (Sup 1) (2003): S103-S112.

11. In vivo efficacy of bone-marrow-coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig, J Biomed Mats Res. Part B-Appl Biomat, 66B (2003):574-580.

12. Repair of Calvarial Defects with Customised Tissue-Engineered Bone Grafts. Part I: Evaluation of Osteogenesis in a 3D Culture System, Tissue Engineering 9 (Sup 1) (2003): S113-S126.

13. Repair of Calvarial Defects with Customised Tissue-Engineered Bone Grafts. Part II: Evaluation of cellular efficiency and efficacy in vivo, Tissue Engineering 9 (Sup 1) (2003): S127-S139.

14. In vivo efficacy of bone-marrow-coated polycaprolactone scaffolds for the reconstruction of orbital defects in the pig, J Biomed Mats Res. Part B-Appl Biomat, 66B (2003):574-580.

15.  Asian Innovation Awards: The Winners 2004, Far Eastern Economic Review, October 21, (2004):36.

16.  Healing Heads, Far Eastern Economic Review, October 21, (2004):28-39.

17. Plugging Bone the Painless Way , Innovation, The Magazine of Research and Technology, Vol.4, No. 3, (2004):60-61.

18. Singapore team strikes gold for innovation, The Straits Times, Wed, Oct 13, 2004.

19. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds, Biomaterials, 25 (2004):5499-5506.

20. Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging, Biomaterials, 25 (2004): 4947-4954

22. Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2, Biomaterials, 26 (2005): 3739-3748

23. An evaluation of PCL-TCP composites as delivery systems for platelet-rich plasma. Journal of Controlled Release; 107 (2005): 330-342.

24. Flow modelling within a scaffold under the influence of uni-axial and bi-axial bioreactor rotation, Journal of Biotechnology, 119 (2005): 181–196

25. Osteogenic differentiation of mesenchymal progenitor cells in computer designed fibrin-polymer-ceramic scaffolds manufactured by fused deposition modeling J. Mats Sci-Mats Med, 16 (2005):807-819.

26. Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model, Tissue Engineering, 16 (2006):1539-1551.

27.  Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits, Biomaterials,27 (2006): 1071-1080

28.  Cranioplasty after trephination using a novel biodegradable burr hole cover: Technical case report, J Neurosurgery, 58 Sup 1 (2006): 176-179.

29.  In vitro degradation of novel bioactive polycaprolactone-20% tricalcium phosphate composite scaffolds for bone engineering, Mats Sci and Eng, C,27 (2007): 293-298.

30.  Comparison of the degradation of polycaprilactone and polycaprolactone-(beta-tricalcium phosphate) scaffolds in alkaline medium, Polym Int.,56 (2007):718-728

31.  Polycaprolactone-20% Tricalcium Phosphate Scaffolds in Combination With Platelet-Rich Plasma for the Treatment of Critical-Sized Defects of the Mandible: A Pilot Study, J Oral & Max Surgery 65 (2007): 2195-2205.

32.  Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair, J Biomed Mats Res. Part A, 81A (2007): 888-899.

33.  Combined marrow stromal cell-sheet techniques and high-strength biodegradable composite scaffolds for engineered functional bone grafts, Biomaterials, 28 (2007): 814-824.

34.  The degradation profile of novel, bioresorbable PCL-TCP scaffolds: An in vitro and in vivo study, J Biomedical Matls. Res. Part A, 84A (2008):208-218.

35.  Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions, Biomed. Mater. (UK) 3 (2008):1-15.

36.  Customizing the Degradation and Load-Bearing Profile of 3D Polycaprolactone-Tricalcium Phosphate Scaffolds Under Enzymatic and Hydrolytic Conditions. J Biomed Mater Res.;87B (2008):562-569.

37.  Biological performance of a polycaprolactone-based scaffold used as fusion cage device in a large animal model of spinal reconstructive surgery, Biomaterials, 30 (2009): 5086-5093

38.  The stimulation of healing within a rat calvarial defect by mPCL-TCP/collagen scaffolds loaded with rhBMP-2, Biomaterials, 30 (2009): 2479-2488.

39.  Mandibular defect reconstruction using 3D PCL scaffold in combination with PRP and rhBMP-2: De novo synthesis of bone in a single case, Tissue Engineering, Part A, 15 (2009):493-499

40.  Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo. J Biomed Mater Res.;90A(2009):906-919

41.  Use of Osteoplug polycaprolactone implants as novel burr-hole covers. Singapore Med J.;50 (2009):777-780

42. Patent - World Wide (PCT (WO 2010/044758 A1)) - Resorbable scaffolds for bone repair and long bone tissue engineering, Priority filing: 17th October 2008

43.  A biaxial rotating bioreactor for the culture of fetal mesenchymal stem cells for bone tissue engineering, Biomaterials,30 (2009): 2694-2704.

44.  Calvarial Reconstruction by Customized Bioactive Implant. Handchir Mikrochir Plast Chir. 2010 Dec; 42 (6):369-73.

45.  Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies. Tissue Eng Part B Rev. 2010 Feb;16 (1):93-104.

46.  The evaluation of a biphasic osteochondral implant coupled with an electrospun membrane in a large animal model. Tissue Eng Part A. 2010 Apr, 16 (4):1123-41.

47.  The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cells. Biomaterials. 2010 Jan; 31 (1):38-47.

48.  Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL-TCP scaffolds. Biomaterials. 2010 Nov;.31 (31):7960-70.

49.  Effects of polycaprolactone-tricalcium phosphate, recombinant human bone morphogenetic protein-2 and dog mesenchymal stem cells on bone formation: pilot study in dogs. Yonsei Med J. 2009 Dec 31; 50 (6):825-31.

50.  Surface modification of PCL-TCP scaffolds in rabbit calvaria defects: Evaluation of scaffold degradation profile, biomechanical properties and bone healing patterns. J Biomed Mater Res A. 2010 Jun 15; 93 (4):1358-67.

51.  Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects. Biomaterials. 2010 Feb; 31 (4):608-20.

52.  Porcine bone marrow stromal cell differentiation on heparin-adsorbed poly(e-caprolactone)-tricalcium phosphate-collagen scaffolds. Acta Biomater. 2009 Nov; 5 (9):3305-15.

53.  Repair and regeneration of osteochondral defects in the articular joints. Biomol Eng. 2007 Nov; 24 (5):489-95.

54.  Superior osteogenic capacity for bone tissue engineering of fetal compared with perinatal and adult mesenchymal stem cells. Stem Cells. 2009 Jan; 27 (1):126-37.

55.  Surface modification of PCL-TCP scaffolds improve interfacial mechanical interlock and enhance early bone formation: an in vitro and in vivo characterization. J Biomed Mater Res A. 2010 Jan; 92 (1):311-21.

56.  The evaluation of a biphasic osteochondral implant coupled with an electrospun membrane in a large animal model. Tissue Eng Part A. 2010 Apr; 16 (4):1123-41.

57.  The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cells. Biomaterials. 2010 Jan; 31 (1):38-47.

58.  Polycaprolactone-based fused deposition modeled mesh for delivery of antibacterial agents to infected wounds. Biomaterials. 2011 Jan; 32 (1):279-287.

59.  The Effect of Platelet Rich Plasma on Osteogenesis in a Long Bone Segmental Defect: Is the Platelet Rich Plasma Effective for Bone Reconstruction?, Tissue Engineering and Regenerative Medicine, 7 (2010): 395-400.

60.  Beyond Cell Capture: Antibody Conjugation Improves Hemocompatibility for Vascular Tissue Engineering Applications, Tissue Engineering, Part A, 16 (2010): 2485-2495.

61.  A comparison of bioreactors for culture of fetal mesenchymal stem cells for bone tissue engineering, Biomaterials, 31 (2010):8684-8695.

62.  High tibial osteotomy using polycaprolactone-tricalcium phosphate polymer wedge in a micro pig model, Journal of Bone and Joint Surgery - British Volume, 93-B (2011): 120-125.

63.  Building a better body, The Straits Times, Sat, Jan 13, 2011.

64.  National University of Singapore and Others develop 3D bone implants to improve skull repair , The Better World Report, 2010 Edition

65.  Patent (China)- ZL 200480040532.2 - Bioabsorbable Plug Implants and Method for Bone Tissue Regeneration, Granted 25th Aug 2010, Priority filing: 22nd November 2004.

66.  Patent - US 7968026 B1- Three-Dimensional Bioresorbable Scaffolds for Tissue Engineering Applications, Granted 28th Jun 2011, Priority filing: 20th April 2004.